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Shapely Wellness Way > Blog > Lifestyle > Understanding GLP-1 Medications: A Comprehensive Guide
Lifestyle

Understanding GLP-1 Medications: A Comprehensive Guide

Sam Hubbert
Last updated: April 10, 2025 11:28 am
Sam Hubbert
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4 Min Read
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Your Guide to the Science Behind the Buzz

Glucagon-like peptide-1, or GLP-1, might sound like another obscure medical acronym, but over the past few years, it has become a buzzword in clinics and dinner table conversations. Why? Because of what it can do and who it’s doing it for.

GLP-1 is a hormone naturally produced in our intestines when we eat. It’s part of a family of hormones called incretins, and its job is to help regulate blood sugar by:

  • Stimulating insulin secretion
  • Suppressing glucagon (a hormone that raises blood sugar)
  • Slowing gastric emptying, which keeps us fuller for longer
  • Acting on the brain to reduce appetite

Originally, GLP-1 receptor agonists (GLP-1 RAs) were developed as treatments for type 2 diabetes, a condition marked by insulin resistance and poor blood sugar control. Over time, scientists noticed an interesting side effect: people were losing weight and not just a little. The mechanism made sense: less hunger, slower digestion, better metabolic balance.

This shifted the focus of GLP-1 medications from diabetes management to obesity treatment and eventually to cardiovascular protection and potential neurodegenerative disease therapy.

Popular GLP-1 Medications:

  • Liraglutide (Saxenda, Victoza): Daily injection

How it works: Mimics the GLP-1 hormone to stimulate insulin release, slow gastric emptying, and suppress appetite

Weight effects: Moderate weight loss; typically around 5–8% of body weight

  • Semaglutide (Ozempic, Wegovy, Rybelsus): Weekly injection or daily oral tablet

How it works: Similar to liraglutide, but with a longer half-life, allowing once-weekly dosing

Weight effects: Significant  up to 15% body weight loss in clinical trials (Wegovy)

  • Dulaglutide (Trulicity): Weekly injection

How it works: Activates GLP-1 receptors to improve insulin secretion and glucose control

Weight effects: Moderate; average of 3–5 kg weight loss in most users

  • Tirzepatide (Mounjaro): Dual-acting, weekly injection

How it works: A dual agonist activates both GLP-1 and GIP receptors, enhancing insulin release and appetite suppression more powerfully than GLP-1 alone

Weight effects: Industry-leading  trials show up to 20–22% body weight reduction, even in non-diabetics

These meds support better blood sugar control, curb appetite, and promote significant fat loss, especially when paired with healthy habits.

GLP-1 vs Traditional Medications

Feature GLP-1 Medications Traditional Diabetes/Weight-Loss Meds
Action Mimic natural hormones to control appetite and blood sugar Often target insulin production or fat absorption
Weight Loss Significant, sustained loss Usually mild or incidental
Cardio Benefits Some have proven heart protection Limited in older meds
Administration Injection or oral Oral tablets (mostly)
Hypoglycemia Risk Low (unless used with insulin) Higher with sulfonylureas or insulin

What Can GLP-1 Medications Do?

✅ Sustained weight loss

✅ Reduced appetite and cravings

✅ Improved insulin sensitivity

✅ Cardiovascular protection (in some cases)

✅ Lower HbA1c levels in diabetics

Potential Side Effects:

Like all medications, GLP-1s can come with some side effects:

Nausea or vomiting (usually temporary)

Constipation or diarrhea

Mild fatigue or dizziness

Rarely, pancreatitis or gallbladder issues

*Always consult your healthcare provider before starting any new medication.*

Final Word:

GLP-1 receptor agonists are game changers for those managing diabetes or obesity. While not a magic bullet, they offer powerful tools in a structured, doctor-guided plan. If you’ve hit a plateau or want to explore medication-supported weight loss, it might be time to have a conversation with your doctor.

Credits
Written By Mallika Singh

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